missing translation for 'onlineSavingsMsg'
Learn More
Please login to your online account to display your discounted pricing

Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Manufacturer:  Thermo Scientific™ Lab Vision™ MS595P1ABX

 View more versions of this product

Catalog No. MS595P1ABX


 

Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Host Species: Mouse

Clone: XZ133

Isotype: IgG1

Species Reactivity: Human, Mouse (strong) and Chicken (strong). Does not react with Xenopus. Others not known.

Epitope: aa 620-665

Immunogen: Recombinant human Rb protein corresponding to amino acids 387-928

Molecular Weight: 105kDa

Positive Control: Ls174T, HT29, HUVEC cells

Cellular Localization: Nuclear Ab-5 reacts with the hyperphosphorylated as well as the under phosphorylated form of the Rb protein.

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Retinoblastoma (Rb) Ab-5
Monoclonal
1mg/mL
Concentrated
Recombinant human Rb protein corresponding to amino acids 387-928
100μL
Cancer and Tumor Biology
Monoclonal
Immunoprecipitation
XZ133
Unlabeled
Murine
IgG1
RUO
Primary
Chicken,Human