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Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS595P1ABX

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Catalog No. MS595P1ABX

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Description & Specifications

Specifications

Antigen Retinoblastoma (Rb) Ab-5
Applications Immunoprecipitation
Classification Monoclonal
Clone XZ133
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Chicken
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Recombinant human Rb protein corresponding to amino acids 387-928
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-5, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Host Species: Mouse

Clone: XZ133

Isotype: IgG1

Species Reactivity: Human, Mouse (strong) and Chicken (strong). Does not react with Xenopus. Others not known.

Epitope: aa 620-665

Immunogen: Recombinant human Rb protein corresponding to amino acids 387-928

Molecular Weight: 105kDa

Positive Control: Ls174T, HT29, HUVEC cells

Cellular Localization: Nuclear Ab-5 reacts with the hyperphosphorylated as well as the under phosphorylated form of the Rb protein.

Recommended for:

  • Immunohistochemistry (Not suitable)
  • Western Blotting (Not suitable)
  • Immunofluorescence
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO