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Thermo Scientific™ Lab Vision™ Retinoblastoma (Rb) Ab-1, Mouse Monoclonal Antibody

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-1, Mouse Monoclonal Antibody.

$246.55 - $1,488.39

Specifications

Antigen Retinoblastoma (Rb) Ab-1
Clone 1F8; same as Rb1
Applications Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting
Classification Monoclonal
Host Species Murine
View More Specs


Products ${productFamilyLength}
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
Catalog Number Mfr. No. Formulation Quantity Price Quantity  
MS107B Thermo Scientific™ Lab Vision™
MS107B
Biotinylated Ab with BSA and Azide 1mL Each for $1,488.39
MS107B0 Thermo Scientific™ Lab Vision™
MS107B0
Biotinylated Ab with BSA and Azide 100μL Each for $343.10
MS107B1 Thermo Scientific™ Lab Vision™
MS107B1
Biotinylated Ab with BSA and Azide 500μL Each for $930.78
MS107P Thermo Scientific™ Lab Vision™
MS107P
Purified Ab with BSA and Azide 1mL Each for $1,162.76
MS107P0 Thermo Scientific™ Lab Vision™
MS107P0
Purified Ab with BSA and Azide 100μL Each for $246.55
MS107P1 Thermo Scientific™ Lab Vision™
MS107P1
Purified Ab with BSA and Azide 500μL Each for $728.86
MS107P1ABX Thermo Scientific™ Lab Vision™
MS107P1ABX
Ab without BSA/Azide (Frozen) 100μL Each for $814.20
MS107PABX Thermo Scientific™ Lab Vision™
MS107PABX
Ab without BSA/Azide (Frozen) 200μL Each for $1,232.80
MS107R7 Thermo Scientific™ Lab Vision™
MS107R7
Ready-to-use for IHC (UVLP) 7mL Each for $486.92
Specifications

Description

Provide accurate, reproducible results with the Thermo Scientific™ Retinoblastoma (Rb) Ab-1, Mouse Monoclonal Antibody.

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Host Species: Mouse

Clone: 1F8; same as Rb1

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not known.

Epitope: aa 703-722

Immunogen: Recombinant human Rb protein

Molecular Weight: 105kDa

Positive Control: Ls174T, HT29, HUVEC cells; Normal colon, Breast CA and colon CA

Cellular Localization: Nuclear Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein. It shows no cross reaction with p107 and p130.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunofluorescence
  • Immunoprecipitation (Native and denatured)
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Description & Specifications

Specifications

Retinoblastoma (Rb) Ab-1
Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting,Flow Cytometry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunoprecipitation,Western Blotting
Murine
Cancer and Tumor Biology
Recombinant human Rb protein
1F8; same as Rb1
Monoclonal
RUO
Primary
IgG1