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R&D Systems Recombinant Human Lymphotoxin-alpha/TNF-beta

Tumor Necrosis Factor beta

$292.21 - $292.21

Catalog Number Mfr. No. Price Quantity    


r&d systems
Each for $292.21
Description & Specifications

TNF-beta, also known as lymphotoxin-alpha (LTalpha) and TNF-alpha are two structurally and functionally related proteins that bind to the same cell surface receptors (TNF RI and TNF RII) and produce a vast range of similar, but not identical effects. Mature TNF-beta/LTalpha and TNF-alpha share approximately 35% protein sequence homology, and the biologically active secreted forms of both proteins are trimers. Human and mouse TNF-beta/LTalpha share approximately 74% homology in their amino acid sequence and exhibit cross-species activity. Soluble TNF-beta/LTalpha is a homotrimer in solution. Secreted TNF-beta/LTalpha also complexes with the membrane associated LTbeta/TNFSF3 to generate two types of heterotrimers, LTalpha1/beta2 and LTalpha2/beta1.

N-terminal Sequence Analysis: Met
SDS-PAGE: 17-19 kDa, reducing conditions
Activity: Measured in a cytotoxicity assay using LG–929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. Matthews, N. and M.L. Neale (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 221.The ED50 for this effect is typically 4-20 pg/mL.

The product is shipped at ambient temperature. Upon receipt, store it immediately