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Tocris™ (R)-DRF053 dihydrochloride

Dual CK1/cdk inhibitor

$302.02 - $1,271.06

Specifications

Product Type (R)-DRF053 dihydrochloride
Inhibitors (R)-DRF053 dihydrochloride
Molecular Weight 490.43
Purity >98
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

361010R

 
tocris™
3610/10
10mg Each for $302.02

361050R

 
tocris™
3610/50
50mg Each for $1,271.06
Description & Specifications

Specifications

Product Type (R)-DRF053 dihydrochloride
Inhibitors (R)-DRF053 dihydrochloride
Molecular Weight 490.43
Purity >98

Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells.

  • Chemical Name: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride
  • Formula: C23H27N7O.2HCl
  • CAS Number: 1241675-76-2
  • Solubility: Soluble to 100mM in water and to 100mM in DMSO
  • Purity: >98