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(R)-(-)-Deprenyl hydrochloride, Thermo Scientific Chemicals
Selective MAO-B inhibitor; anti-Parkinsonian agent
Supplier: Thermo Scientific Chemicals J61286MD
Description
(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinsonâs disease, Alzheimerâs disease, Huntingtonâs disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinsonâs disease, Alzheimerâs disease, Huntingtonâs disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.
Solubility
Soluble in water at 100mM
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
Specifications
(R)-(-)-Deprenyl hydrochloride | |
White | |
MFCD00069299 | |
14,8428 | |
Soluble in water at 100mM | |
−12° (c=1 in Water) | |
hydrogen methyl[(2R)-1-phenylpropan-2-yl](prop-2-yn-1-yl)amine chloride | |
26758 | |
223.74 |
14611-52-0 | |
C13H18ClN | |
250 mg | |
selegiline hydrochloride, eldepryl, zelapar, selegiline hcl, l-deprenyl hydrochloride, jumex hydrochloride, --deprenyl hydrochloride, eldepryl hydrochloride, r-n-methyl-n-1-phenylpropan-2-yl prop-2-yn-1-amine hydrochloride, zydis selegiline | |
IYETZZCWLLUHIJ-UTONKHPSSA-N | |
[H+].[Cl-].C[C@H](CC1=CC=CC=C1)N(C)CC#C | |
223.74 | |
CHEBI:9087 | |
Crystalline Powder |
Chemical Identifiers
14611-52-0 | |
223.74 | |
IYETZZCWLLUHIJ-UTONKHPSSA-N | |
26758 | |
hydrogen methyl[(2R)-1-phenylpropan-2-yl](prop-2-yn-1-yl)amine chloride |
C13H18ClN | |
MFCD00069299 | |
selegiline hydrochloride, eldepryl, zelapar, selegiline hcl, l-deprenyl hydrochloride, jumex hydrochloride, --deprenyl hydrochloride, eldepryl hydrochloride, r-n-methyl-n-1-phenylpropan-2-yl prop-2-yn-1-amine hydrochloride, zydis selegiline | |
CHEBI:9087 | |
[H+].[Cl-].C[C@H](CC1=CC=CC=C1)N(C)CC#C |
Safety and Handling
GHS H Statement
H315-H319
Causes skin irritation.
Causes serious eye irritation.
P264b-P280-P302+P352-P305+P351+P338-P332+P313-P362
H315-H319
RTECSNumber : DA0292500
TSCA : No
Recommended Storage : Ambient temperatures
RUO – Research Use Only