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R&D Systems b-AP15/VLX1500

Specifically inhibits the 19S regulatory particle-associated deubiquitinases USP14 and UCHL5, resulting in the accumulation of intracellular polyubiquitin

Manufacturer: r&d systems  I19701M

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Catalog No. I19701M

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Description & Specifications


Product Type 19S proteasome inhibitor
Inhibitors 19S proteasome
Molecular Weight 419.39
Quantity 1mg

b-AP15 has been shown to inhibit tumor progression in at least four solid tumor models, and also inhibits organ infiltration in an acute myeloid leukemia (AML) model.

  • Potent, reversible, cell-permeable inhibitor
  • Purity >97% by HPLC
  • Decreases HCT-116 cell viability at 72 hours (EC50 = 0.4μM)