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MP Biomedicals™ Q-VD-OPH, MP Biomedicals™

Specifically designed for in-vivo research. Q-VD-OPH, MP Biomedicals is synthesized using proprietary technology as a cell-permeable, irreversible caspase inhibitor. The OPH trap, with its superior potency, proven cell permeability and minimal toxicity, p

Manufacturer:  MP Biomedicals™ 03OPH10901

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Catalog No. MP3OPH10901



Description

Description

The Q-VD-OPH irreversibily binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and removal of damaged and mutated cells.

Caspases, which act as molecular chainsaw, are the central components of apoptosis response. Caspases are Cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis.

  • Exceptional alternative to the Fluoromethylketone family of inhibitors (these compounds form the basis for important new drug candidates for a wide variety of disease targets)
  • Nontoxic&mdash:preliminary study showed no evidence of toxicity in mice injected intraperitoneally with more than 1000mg/kg
  • Improved potency—IC50 values against purified caspases are in the nanomolar range; in an in vitro cell based assay, greater than 90% inhibition of apoptosis was achieved)
  • Optimal dilutions should be determined by the laboratory for each specific application
Specifications

Specifications

513.49
1mg
−20°C
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