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Alfa Aesar™ Pyridine-2,4-dicarboxylic acid, 98%, may cont. up to ca 10% water

$87.05 - $917.84

Chemical Identifiers

Chemical Name or Material Pyridine-2,4-dicarboxylic acid
CAS 499-80-9
Molecular Formula C7H5NO4
Formula Weight 167.12g/mol
MDL Number MFCD00149413
Beilstein 131631
Synonym Lutidinic acid
View More Specs
Products
Catalog Number Mfr. No. Quantity Price Quantity    

AAA1440906

 
alfa aesar™
A14409-06
5g Each for $87.05

AAA1440914

 
alfa aesar™
A14409-14
25g Each for $286.51

AAA1440922

 
alfa aesar™
A14409-22
100g Each for $917.84
Description & Specifications

Specifications

Melting Point ≈245°C (dec.)
pH 2.5 to 3.5
Quantity 5g
Chemical Name or Material Pyridine-2,4-dicarboxylic acid
CAS 499-80-9
Assay 98%
Assay Percent Notes may cont. up to ≈10% water
Molecular Formula C7H5NO4
Formula Weight 167.12g/mol
MDL Number MFCD00149413
Beilstein 131631
Synonym Lutidinic acid
Health Hazard 1 Warning
Health Hazard 2 GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Health Hazard 3 GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.
TSCA TSCA

Applications
It is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. It blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,3 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), It modulates hypoxia inducing factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-β-lactamase.8 2,4-PDCA also affects and is translocated by organic anion transporters.

Solubility
Soluble in water at 20°C 4.5 g/L.

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Safety and Handling

Warning

GHS P Statement
P261-P280-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapors/spray.
Wear protective gloves/protective clothing/eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.
Store locked up.
Dispose of contents/container in accordance with local/regional/national/international regulations.

GHS H Statement
H315-H319-H335
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.