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Puromycin dihydrochloride, 98%, Thermo Scientific Chemicals
Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis.
Supplier: Thermo Scientific Chemicals J61278MB
Description
It also exhibits antitumor activity in studies on brain tumor cells. Puromycin is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3¢-terminal end of aminoacyl-tRNA. It has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis
Applications
• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.
Specifications
Puromycin Dihydrochloride | |
Powder | |
168°C to 170°C | |
MFCD00150080 | |
14,7943 | |
MKSVFGKWZLUTTO-MLYJQVMKNA-N | |
(2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride | |
131632508 | |
99% | |
25 mg |
Puromycin dihydrochloride | |
58-58-2 | |
C22H31Cl2N7O5 | |
3853613 | |
Soluble in water | |
Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1 | |
544.43 | |
544.44 | |
White |
Chemical Identifiers
58-58-2 | |
544.43 | |
MKSVFGKWZLUTTO-MLYJQVMKNA-N | |
Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1 |
C22H31Cl2N7O5 | |
MFCD00150080 | |
131632508 |
Safety and Handling
GHS H Statement
H302
Harmful if swallowed.
P264b-P270-P301+P312-P330-P501c
H302
EINECSNumber : 200-387-8
RTECSNumber : AU355000
TSCA : No
Recommended Storage : Store at -20°C
RUO – Research Use Only