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PU.1 Mouse anti-Human, Mouse, Clone: phpu13, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $303.05

Specifications

Antigen PU.1
Clone phpu13
Host Species Mouse
Species Reactivity Human, Mouse
Applications Immunocytochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122883

 
affymetrix
14981982
100μg Each for $303.05

501122882

 
affymetrix
14981980
25μg Each for $129.05
Description & Specifications

Specifications

Antigen PU.1
Clone phpu13
Host Species Mouse
Species Reactivity Human, Mouse
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal phpu13 recognizes human and mouse PU.1, a member of the ets family of transcription factors. This 42kDa protein was originally identified as Spi-1, a proto-oncogene, for its role in Friend virus-induced murine erythroleukemia. Expression of PU.1 plays a critical role in lymphocyte and myeloid development. Knock-out mice are neonatal lethal and lack myeloid, T and B cells. In addition erythroid development is also altered. Protein expression levels help guarantee proper development; higher levels in myeloid cells compared to lymphocytes. PU.1 controls transcription of several proteins including CD11b, CD18, Gata2, IRF4, CD20, CD10, and CD79.

Disruption of PU.1 expression may play a role in several specific leukemias; such as B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, and nodular lymphocyte predominant Hodgkin.