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PU.1 Mouse anti-Human, Mouse, Clone: phpu13, eBioscience™

Mouse Monoclonal Antibody

$120.12 - $281.16

Specifications

Antigen PU.1
Clone phpu13
Host Species Murine
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122883 Life Technologies
LS14981982
100μg Each for $281.16
501122882 Life Technologies
LS14981980
25μg Each for $120.12
Specifications

Description

The monoclonal phpu13 recognizes human and mouse PU.1, a member of the ets family of transcription factors. This 42kDa protein was originally identified as Spi-1, a proto-oncogene, for its role in Friend virus-induced murine erythroleukemia. Expression of PU.1 plays a critical role in lymphocyte and myeloid development. Knock-out mice are neonatal lethal and lack myeloid, T and B cells. In addition erythroid development is also altered. Protein expression levels help guarantee proper development; higher levels in myeloid cells compared to lymphocytes. PU.1 controls transcription of several proteins including CD11b, CD18, Gata2, IRF4, CD20, CD10, and CD79.

Disruption of PU.1 expression may play a role in several specific leukemias; such as B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, and nodular lymphocyte predominant Hodgkin.
Description & Specifications

Specifications

PU.1
Murine
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
phpu13
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin)
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL