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Thermo Scientific™ Lab Vision™ pS2/pNR-2 Estrogen-Regulated Protein Ab-2, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ pS2/pNR-2 Estrogen-Regulated Protein Ab-2, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS199P1ABX

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Catalog No. MS199P1ABX

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Description & Specifications

Specifications

Antigen pS2/pNR-2 Estrogen-Regulated Protein Ab-2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone GE2; previously R47/94
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Formulation Ab without BSA/Azide (Frozen)
Host Species Mouse
Immunogen A Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCF-YPNTIDVPPEEECEF (aa 57-84) from C-terminus of human pS2 protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cancer and Tumor Biology
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ pS2/pNR-2 Estrogen-Regulated Protein Ab-2, Mouse Monoclonal Antibody.

pS2 is a cysteine-rich, 6.5kDa protein found in both estrogen-dependent (breast tumors) and estrogen-independent tissues (normal stomach mucosa). About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is primarily expressed in estrogen receptor-positive breast tumors.

Host Species: Mouse

Clone: GE2; same as R47/94

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: aa 57-84

Immunogen: A synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCF-YPNTIDVPPEEECEF (aa 57-84) from C-terminus of human pS2 protein

Molecular Weight: 6.5kDa

Positive Control: Normal stomach or breast CA

Cellular Localization: Cytoplasmic Antibody to pS2 is reportedly useful in identifying a subset of estrogen-dependent breast tumors which may respond to endocrine therapy.

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Affinity Purification

Note:

USA: RUO; Int'l: RUO