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Tocris™ PRT 4165

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

$96.39 - $404.83

Specifications

Product Type PRT 4165
Inhibitors PRT 4165
Molecular Weight 235.24
Purity >99
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 Disclaimers

For Research Use Only

Products
Catalog Number Mfr. No. Quantity Price Quantity    

504710R

 
tocris™
5047/10
10mg Each for $96.39

504750R

 
tocris™
5047/50
50mg Each for $404.83
Description & Specifications

Specifications

Product Type PRT 4165
Inhibitors PRT 4165
Molecular Weight 235.24
Purity >99

Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo.

  • Chemical Name: 2-(3-Pyridinylmethylene)-1H-Indene-1,3(2H)-dione
  • Formula: C15H9NO2
  • CAS Number: 31083-55-3
  • Solubility: Soluble to 100mM in DMSO and to 5mM in 1eq. HCl with gentle warming
  • Purity: >99