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Thermo Scientific™ ProPac™ WCX-10 LC Columns

Separate proteins and their variants using these weak cation-exchange columns with exceptionally high resolution.

Manufacturer: thermo scientific™  SP5512

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Catalog No. DXSP5512


Description & Specifications


Column Type Ion Exchange
Type Column Set (3 columns, 1 lot)
Carbon Load -
USP Type N/A
Endcapped -
Flow Rate 1mL/min.
Max. Pressure 3000psi
Mobile Phase Compatibility pH 2-12, 80% compatible with acetonitrile and acetone, compatible with nonionic and zwitterionic detergents, incompatible with cationic detergents
Packing Material Spherical, non-porous polymer
Particle Size 10µm
Temperature 60°C
Pore Size Non-porous
pH 2 to 12
Stationary Phase Carboxylate
Surface Area -
Length (Metric) 250mm
Technique Protein/Cation Exchange
Column Format Column Set (3 columns, 1 lot)
Diameter (Metric) 4mm

Use Thermo Scientific™ ProPac™ WCX-10 LC Columns to provide exceptionally high resolution for separations of proteins and their variants. Based on stationary phases composed of 10µm nonporous polymeric beads, ProPac columns resolve isoforms that differ by a single charged residue. A thin, hydrophilic layer grafted to the particle core eliminates unwanted secondary interactions. The cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

Multiple Formats for Greater Flexibility

  • ProPac WCX-10 column is a weak cation-exchanger with a carboxylate functional group
  • Column sizes range from 2mm I.D., for analytical work, up to 22mm I.D. for semi-prep work
Superior Performance for Protein Analysis
  • Ideal for characterization and quality control assessment of MAbs and other proteins
  • Well-suited for characterization of related protein variants including deamidation and MAb lysine truncation variants
  • Unequaled high-resolution separations
  • Unmatched column-to-column and lot-to-lot reproducibility eliminates column variability as a concern in stability and QA/QC testing