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Promega™ VivoGlo™ Caspase-3/7 Substrate (Z-DEVD-Aminoluciferin, Sodium Salt)


A firefly luciferase prosubstrate containing the DEVD tetrapeptide sequence recognized by caspase-3 and -7

Manufacturer: promega™  P1781

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Catalog No. PRP1781

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Description & Specifications

Specifications

Molecular Weight 871.9
For Use With (Application) Eliminate potential interference in assays due to the presence of endotoxins, in-vivo bioluminescence imaging applications
Quantity 50mg
Storage Requirements -20°C

  • Upon activation of caspase-3 or -7, the DEVD peptide is cleaved, and the liberated aminoluciferin reacts with luciferase to generate measurable light
  • Cleavage has been shown in in cellulo and in vivo systems
  • The substrate has a minimum solubility of 500mg/mL in PBS, and the resulting solution is stable for at least three days at room temperature
  • Injection is usually done via the intraperitoneal route, and imaging is generally started ten minutes after injection