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Promega™ Luminogenic Enzyme Substrates


The pro-luciferin substrates can be used to monitor the activity of specific isoforms of cytochrome P450 or NAT2 as indicated in the name of the substrate

Manufacturer: promega™  V8920

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Catalog No. PRV8920

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Description & Specifications

Specifications

Substrate Type Luciferin
Substrate Quantity 10mL
For Use With (Application) Monitor the activity of specific isoforms of cytochrome P450 or NAT2
pH 7.2
Includes 10mL luciferin detection reagent and 10mL reconstitution buffer

  • Luciferin-NAT2 is an excellent substrate for N-acetyltransferase 2 (NAT2), a phase II biotransformation enzyme that acetylates aromatic amine groups on xenobiotic compounds; shows little to no cross-reactivity with NAT1
  • Luciferin-MultiCYP is a promiscuous substrate that reacts with at least 21 P450 isoforms and is useful for measuring net CYP activity in a mixed population of P450s

Luciferin Detection Reagent†, ‡ must be used in combination with the above pro-luciferin substrates. Use Mfr. Nos. V8920/V8921 with P1721, P1741, P1621, P1651 and P1661. Mfr. Nos. V8930/V8931 must be used with P1671 and P1731, as these substrates are ester derivatives.