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Promega™ Caspase Inhibitors

Solubilized in DMSO for easy addition to cell culture extracts

Manufacturer: promega™  G7231

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Catalog No. PR-G7231

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Description & Specifications


Product Name Z-VAD-FMK Caspase Inhibitor
Format Liquid
Concentration 20μm
Color Colorless
Inhibitors Z-VAD-FMK Caspase
Quantity 50μL
For Use With (Application) Irreversibly binds to the catalytic site of Caspase Proteases and can inhibit induction of apoptosis
Storage Requirements -20°C

Z-VAD-FMK (carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone) is a cell-permeant pan caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and can inhibit induction of apoptosis. For inhibition of apoptosis, Z-VAD-FMK should be added at the same time that apoptosis is induced. Z-VAD-FMK is provided at 20mM in DMSO for convenient addition to cell culture or extracts. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. The suggested concentration for use in the anti-Fas mAb-treated Jurkat cell culture model system is 20μM.
Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity. The concentration of inhibitor required to inhibit caspase activity must be determined empirically for each system. Ten micromolar inhibitor is sufficient to inhibit caspase activity in extracts of apoptotic THP-1 cells.

  • Z-VAD-FMK is cell permeable and inhibits apoptosis in situ
  • Ac-DEVD-CHO inhibits caspase-3/7 activity