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Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) Mouse, Clone: 12E3, eBioscience™

Mouse Monoclonal Antibody

$133.32 - $322.08

Specifications

Antigen Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Clone 1.20E+04
Host Species Murine
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen),Microscopy
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122768 Life Technologies
LS14911880
25μg Each for $133.32
501122769 Life Technologies
LS14911882
100μg Each for $322.08
Specifications

Description

The monoclonal antibody 12E3 specifically recognizes polysialylated neural cell adhesion molecule (PSA-NCAM) in human, mouse and rat. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.
Description & Specifications

Specifications

Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Murine
Immunocytochemistry,Immunohistochemistry (Formalin/Paraffin),Immunohistochemistry (Frozen),Microscopy
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL
1.20E+04
Human, Mouse, Rat
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer