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Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) Mouse, Clone: 12E3, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $346.55

Specifications

Antigen Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Clone 1.20E+04
Host Species Mouse
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122768

 
affymetrix
14911880
25μg Each for $143.55

501122769

 
affymetrix
14911882
100μg Each for $346.55
Description & Specifications

Specifications

Antigen Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Clone 1.20E+04
Host Species Mouse
Species Reactivity Human, Mouse, Rat
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody 12E3 specifically recognizes polysialylated neural cell adhesion molecule (PSA-NCAM) in human, mouse and rat. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.