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Pokemon (LRF) Armenian Hamster anti-Human, eFluor 660, Clone: 13E9, eBioscience™

Armenian Hamster Monoclonal Antibody

$187.05 - $433.55

Specifications

Antigen Pokemon (LRF)
Clone 1.30E+10
Host Species Armenian Hamster
Gene Alias Leukemia/lymphoma-related factor
Species Reactivity Human
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124337

 
affymetrix
50330980
25μg Each for $187.05

501124338

 
affymetrix
50330982
100μg Each for $433.55
Description & Specifications

Specifications

Antigen Pokemon (LRF)
Clone 1.30E+10
Host Species Armenian Hamster
Gene Alias Leukemia/lymphoma-related factor
Species Reactivity Human
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This monoclonal antibody reacts with human Leukemia/lymphoma-related factor (LRF). This 65kDa protein is also known as POKEMON, FBI-1, and Zbtb7a. LRF is a member of the POK family of transcriptional repressors, and is expressed in hematopoietic stem cells, T and B lymphocytes, macrophages, and erythroid cells. This protein is also highly expressed in human non-Hodgkin’s lymphoma tissues and diffuse large B-cell lymphomas, demonstrating its prominent role in oncogenic transformation. Studies have demonstrated that LRF is also involved in B cell lineage commitment and development by opposing Notch signaling. Moreover, LRF is critical for erythroid terminal differentiation in the bone marrow by inhibiting Bim-mediated apoptosis. Finally, LRF interacts with Bcl-6 in germinal center B cells.