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Invitrogen™ PLK4 Recombinant Human Protein DFS Item

PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases. Recombinant human PLK4 (1-836) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

$594.00 - $9,080.00

Specifications

Host Species Human
Protein Tag GST Tag
Recombinant Yes
View More Specs

Products 3
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
PV6394 View Documents Invitrogen™
LSPV6394
10μg Each for $594.00
 
PV6395 View Documents Invitrogen™
LSPV6395
100μg Each for $2,030.00
 
PV6396 View Documents Invitrogen™
LSPV6396
1mg Each for $9,080.00
 
Description

Description

PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells.The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use
Specifications

Specifications

Human
GST Tag
Yes