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Thermo Scientific™ Lab Vision™ Plastin-L Ab-1, Mouse Monoclonal Antibody


Provide accurate, reproducible results with the Thermo Scientific™ Plastin-L Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS1326P1ABX

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Catalog No. MS1326P1ABX

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Description & Specifications

Specifications

Antigen Plastin-L Ab-1
Applications Immunofluorescence
Applications Immunoprecipitation
Applications Western Blotting
Classification Monoclonal
Clone LPL4A.1
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Human recombinant L-plastin protein
Isotype IgG1
Quantity 100µL
Regulatory Status RUO
Research Discipline Cytoskeletal Protein
Type Primary

Provide accurate, reproducible results with the Thermo Scientific™ Plastin-L Ab-1, Mouse Monoclonal Antibody.

L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosteronse in andrgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.

Host Species: Mouse

Clone: LPL4A.1

Isotype: IgG1

Species Reactivity: Human. Does not react with Mouse. Others not known.

Epitope: Headpiece region

Immunogen: Human recombinant L-plastin protein

Molecular Weight: 62kDa

Positive Control: Human polymorphonuclear neutrophils and monocytes, MCF-7, Jurkat cells

Cellular Localization: Cytoplasmic

Recommended for:

  • Western Blotting
  • Immunofluorescence (Fixed in methanol or 3% paraformaldehyde)
  • Immunoprecipitation (Native)

Note:

USA: RUO; Int'l: RUO