Thermo Scientific™ Lab Vision™ Plastin-L Ab-1, Mouse Monoclonal Antibody
Provide accurate, reproducible results with the Thermo Scientific™ Plastin-L Ab-1, Mouse Monoclonal Antibody.
Manufacturer: Thermo Scientific™ Lab Vision™ MS1326PABX
Provide accurate, reproducible results with the Thermo Scientific™ Plastin-L Ab-1, Mouse Monoclonal Antibody.L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosteronse in andrgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.
Host Species: Mouse
Species Reactivity: Human. Does not react with Mouse. Others not known.
Epitope: Headpiece region
Immunogen: Human recombinant L-plastin protein
Molecular Weight: 62kDa
Positive Control: Human polymorphonuclear neutrophils and monocytes, MCF-7, Jurkat cells
Cellular Localization: Cytoplasmic
- Western Blotting
- Immunofluorescence (Fixed in methanol or 3% paraformaldehyde)
- Immunoprecipitation (Native)
USA: RUO; Int'l: RUO
|Human recombinant L-plastin protein|