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PIR-A/B Rat anti-Mouse, APC, Clone: 10-1-PIR, eBioscience™

Rat Monoclonal Antibody

$143.55 - $390.05

Specifications

Antigen PIR-A/B
Clone 10-1-PIR
Host Species Rat
Gene Alias PirA, PirB, PIR A, PIR-A, PIR B, PIR-B, PIR AB, PIR-AB, PIRAB
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015136

 
affymetrix
17310180
25μg Each for $143.55

5015137

 
affymetrix
17310182
100μg Each for $390.05
Description & Specifications

Specifications

Antigen PIR-A/B
Clone 10-1-PIR
Host Species Rat
Gene Alias PirA, PirB, PIR A, PIR-A, PIR B, PIR-B, PIR AB, PIR-AB, PIRAB
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This 10-1-PIR monoclonal antibody reacts with mouse paired Ig-like receptors of activating (PIR)-A and -B. These cell surface glycoproteins, which contain six extracellular Ig-like domains with distinct transmembrane and cytoplasmic regions, are expressed together on B lymphocytes, dendritic cells, macrophages, granulocytes, platelets, and mast cells. However, expression of PIR-A/B has not been observed on T cells, NK cells, and erythrocytes. The PIR-A receptor interacts with signaling molecules containing immunoreceptor tyrosine-based activation motifs (ITAMs) which lead to its activating function. In contrast, the PIR-B receptor associates with proteins possessing immunoreceptor tyrosine-based inhibitory motifs (ITIMs); therefore, this receptor has been shown to have an inhibitory function. PIRs bind MHC class I to modulate cell signaling and homeostasis of the immune system. Moreover, PIR-B knockout mice have been shown to exhibit susceptibility to Salmonella infection.

Crossblocking studies indicate that 10-1-PIR recognizes a different epitope from 6C1 (cat. no. 46-5978).