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Invitrogen™ PIK3CD/PIK3R1 (p110 delta/p85 alpha) Recombinant Human Protein, His tag DFS Item

Phosphatidylinositol 3-kinase (PI3K) is composed of a catalytic subunit (p110δ) and a regulatory subunit (p85α in this case), which are encoded by the PIK3CD and PIK3R1 genes. PI3K phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring.

Manufacturer:  Invitrogen™ LSPV6451

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Catalog No. PV6451



Description

Description

Phosphatidylinositol 3-kinase (PI3K) plays a role in oncogenic transformation and is consistently expressed at a high level in AML blast cells. PI3K can play a selective role in the amplification of phosphatidylinositol (3,4,5) trisphosphate (PIP3) levels that leads to neutrophil polarization, and regulates directional migration, but not random locomotion. The PI3K signaling pathway is involved in immune responses relevant to the pathogenesis of rheumatoid arthritis and other inflammatory diseases.

  • Available in 3 convenient sizes
  • Validated in our Adapta™ and Kinase Binding assays
  • A full length protein that can help advance your research when used with validated assays
Specifications

Specifications

Kinase Assay
Storage buffer: 50 mM sodium phosphate (pH 7.0), 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, and 25% glycerol.

Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
Dry Ice
Full Length
Human
84.7 kDa, 120.6 kDa
p110 delta/p85 alpha, phosphoinositide-3-kinase, p110δ/p85α, regulatory subunit 1 (alpha)
PI3 Kinase Family
NP_005017.3, NP_852664.1
Life Technologies™
Baculovirus
Drug Development
5293, 5295
20μg
PIK3CD, PIK3R1
His Tag
Documents