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Invitrogen™ PIK3CB/PIK3R1 (p110 beta/p85 alpha) Recombinant Human Protein DFS Item

PIK3CB/PIK3R1 (p110β/p85α) is a phosphoinositide-3-kinase (PI3K) comprised of a catalytic subunit, p110β, and a regulatory subunit, p85α, encoded by the PIK3CB and PIK3R1 genes respectively.

Manufacturer:  Invitrogen™ LSPV6456

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Catalog No. PV6456



Description

Description

As with other members of the PI3K family, p110β has important regulatory roles in cellular processes including cell survival, proliferation, and differentiation. It affects growth factor signaling and survival by phosphorylating inositol lipids. PTEN-deficient cancer cells have been observed to depend on p110β signaling.

  • Available in 3 convenient sizes
  • Validated in our Adapta™ and Kinase Binding assays
  • A full-length protein that can help advance your research when used in validated assays
Specifications

Specifications

NP_852664.1|NP_006210.1
50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
84.7kDa|123.7kDa
Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.
phosphatidylinositol-4|p110β/p85α|p110 beta/p85 alpha|5-bisphosphate 3-kinase
Baculovirus
Human
His Tag
Target & Lead Identification & Validation|Kinase Biology|Kinase Proteins & Expression Reagents|Biochemical Kinase Assays|Protein Biology|Enzyme & Protein Activity Assays|Kinase Activity|Protein Assays and Analysis|Industrial & Applied Science|Pharma & Biopharma
PIK3CB, PIK3R1
1mg
Full Length, Recombinant, Active
Kinase Assay
PI3 Kinase
Yes
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