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Thermo Scientific™ Pierce™ Sulfo-SMCC Crosslinker

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Manufacturer: thermo scientific™  PI22322

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Catalog No. PI22322

  • / Pack

Description & Specifications


Spacer Arm Length 8.3Å
Membrane Permeable No
Molecular Weight 436.37
PEGylated No
Quantity 50mg
Sufficient For 115mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Chemical Reactivity Amine-to-Sulfhydryl
Water Soluble Yes
Cleavable No
Description Pierce Sulfo-SMCC
Formulation Sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate; powder solid

Thermo Scientific™ Pierce Sulfo-SMCC is a very popular, water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 Ås).


  • Water-soluble
  • Reactive groups: sulfo-NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups