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Thermo Scientific™ Pierce™ Sulfo-SMCC Crosslinker

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Manufacturer: thermo scientific™  22122

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Catalog No. PI22122

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Description & Specifications


PEGylated No
Quantity 1g
Cleavable No
Water Soluble Yes
Spacer Arm Length 8.3Å
Formulation Sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate; powder solid
Molecular Weight 436.37
Sufficient For 2292mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Description Pierce Sulfo-SMCC
Chemical Reactivity Amine-to-Sulfhydryl
Membrane Permeable No

Thermo Scientific™ Pierce Sulfo-SMCC is a very popular, water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 Ås).


  • Water-soluble
  • Reactive groups: sulfo-NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups