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Thermo Scientific™ Pierce™ Sulfo-SMCC Crosslinker

Crosslink amines to sulfhydryls with this mid-length, water-soluble crosslinker made of NHS-ester and maleimide groups at ends of a cyclohexane-containing, 8-atom spacer arm.

Manufacturer: thermo scientific™  22122

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Catalog No. PI22122

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Description & Specifications


Membrane Permeable No
Molecular Weight 436.37
PEGylated No
Quantity 1g
Sufficient For 2292mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Chemical Reactivity Amine-to-Sulfhydryl
Spacer Arm Length 8.3Å
Water Soluble Yes
Cleavable No
Description Pierce Sulfo-SMCC
Formulation Sulfosuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate; powder solid

Thermo Scientific™ Pierce Sulfo-SMCC is a very popular, water-soluble, amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length cyclohexane spacer arm (8.3 Ås).


  • Water-soluble
  • Reactive groups: sulfo-NHS ester and iodoacetyl
  • Reactive toward: amino and sulfhydryl groups