Please login to your online account to display your discounted pricing

Thermo Scientific™ Pierce™ Sulfo-NHS Crosslinker

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Manufacturer: thermo scientific™  PI24520

 View more versions of this product

Catalog No. PI24520

  • / Pack of 8 Each

Description & Specifications


Spacer Arm Length
Molecular Weight 217.13
Formulation N-Hydroxysulfosuccinimide; solid
Storage Requirements Store as detailed on product information sheet.
PEGylated No
Water Soluble Yes
Quantity 8 x 2mg
Description Pierce Sulfo-NHS, No-Weigh Format
Membrane Permeable Yes
Chemical Reactivity Carboxyl-to-Amine
Sufficient For 15mL of typical 1X (5mM) reaction solution (total), or 8 separate uses

Thermo Scientific™ Pierce Sulfo-NHS is pure N-hydroxysulfosuccinimide, the essential compound needed to prepare water-soluble, amine-reactive NHS-ester crosslinkers or to enhance conjugation efficiencies when using the carbodiimide EDC.


  • Forms an acyl amino ester with carboxyl groups when used with the EDC
  • Sulfo-NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
  • Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
  • Sulfo-NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
  • Reactive groups: Sulfo-NHS
  • Reactive toward: amino groups (upon activation of carboxylates)