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Thermo Scientific™ Pierce™ Sodium Deoxycholate

Water-soluble, ionic detergent used in cell lysis buffers (e.g., RIPA buffer) to disrupt protein interactions for liposome and membrane protein isolation.

Manufacturer: thermo scientific™  89905*

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Catalog No. PI89905

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Description & Specifications


Properties Ionic, Dialyzable
Description Sodium Deoxycholate
Quantity 25g
Formulation Sodium deoxycholic acid

Thermo Scientific™ Sodium Deoxycholate is an ionic detergent that is especially useful for disrupting and dissociating protein interactions.

Sodium deoxycholate (deoxycholic acid) is a water-soluble, bile-acid, ionic detergent commonly used in protein methods. It is most frequently used as a component of cell lysis buffers (e.g., RIPA buffer) but also has been used for liposome preparation, isolation of membrane proteins and lipids, preventing nonspecific binding in affinity chromatography and a cell culture media supplement.


  • Popular anionic, bile-acid detergent for many laboratory uses
  • Effective in disrupting and dissociating many types of protein interaction
  • Can be removed from solution by dialysis
  • Useful for elution or regeneration of certain kinds of affinity columns
  • High-purity compound with low UV absorptivity

Detergent Properties:

  • Alternative Names: Sodium deoxycholic acid; deoxycholate, sodium salt
  • Chemical Name: 3, 12-α-Dihydroxy-5β-cholan-24-oic acid, monosodium salt
  • Molecular Weight: 414.6
  • Detergent Class: Ionic (anionic)
  • Aggregation Number: 5 (average)
  • Micelle Molecular Weight: 2000 (average)
  • Critical Micelle Concentration (CMC): 2 to 6mM (0.083 to 0.249%, w/v)
  • Cloud Point: Unknown
  • Dialyzable: Yes