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Thermo Scientific™ Pierce™ Iodoacetic Acid

Get rapid carboxymethylation of reduced cysteine residues with Thermo Scientific™ Pierce™ Iodoacetic Acid and Iodoacetamide.

$137.26 - $254.02

Specifications

Chemical Reactivity Sulfhydryl
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Products ${productFamilyLength}
Catalog Number Mfr. No. Description Price Quantity  
Catalog Number Mfr. No. Description Price Quantity  
PI35603 Thermo Scientific™
PI35603
Iodoacetic Acid Pack for $137.26
PI90034 Thermo Scientific™
90034
Iodoacetamide, Single-Use Each for $254.02
Specifications

Description

Get rapid carboxymethylation of reduced cysteine residues with Thermo Scientific™ Pierce™ Iodoacetic Acid and Iodoacetamide.

Iodoacetic Acid (IAA) can react with several protein functional groups but is typically used for specific S-carboxymethylation of sulfhydryls (reduced cysteines).

Iodoacetic acid reacts with sulfhydryls on cysteines, imidazolyl side chain nitrogens of histidines, the thioether of methionine and the primary amine group of lysines.The rate of reaction and specificity is dependent on the ionization level, which can be manipulated by the pH of the reaction condition.

Highlights:
  • React at slightly alkaline pH for specific S-carboxymethylation of free sulfhydryls
  • React at low pH for specific carboxymethylation of methionines
  • React at high pH to favor carboxymethylation of histidines and lysines
  • Methylate reduced cysteine peptide fragments in protease digests for mass spectrometry
Description & Specifications

Specifications

Sulfhydryl