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Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Manufacturer: thermo scientific™  PI21658

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Catalog No. PI21658

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Description & Specifications


Spacer Arm Length 11.4Å
Sufficient For 43mL of typical 1X (1mM) reaction solution (total), or 8 separate uses
Description Pierce DSS
Chemical Reactivity Amine-to-Amine
Molecular Weight 368.34
Water Soluble No
Cleavable No
Quantity 8 x 2mg
Membrane Permeable Yes
Formulation Disuccinimidyl suberate; powder solid
PEGylated No

Thermo Scientific™ Pierce DSS, also called disuccinimidyl suberate, is noncleavable and membrane permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces