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Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Manufacturer: thermo scientific™  PI21655

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Catalog No. PI21655

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Description & Specifications


Spacer Arm Length 11.4Å
Cleavable No
Quantity 50mg
Membrane Permeable Yes
Sufficient For 136mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Formulation Disuccinimidyl suberate; powder solid
Chemical Reactivity Amine-to-Amine
Water Soluble No
Molecular Weight 368.34
Description Pierce DSS
PEGylated No

Thermo Scientific™ Pierce DSS, also called disuccinimidyl suberate, is noncleavable and membrane permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces