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Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Manufacturer: thermo scientific™  PI21555

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Catalog No. PI21555

  • / Pack

Description & Specifications


Spacer Arm Length 11.4Å
Chemical Reactivity Amine-to-Amine
Formulation Disuccinimidyl suberate; powder solid
Description Pierce DSS
Sufficient For 2715mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Membrane Permeable Yes
PEGylated No
Cleavable No
Molecular Weight 368.34
Water Soluble No
Quantity 1g

Thermo Scientific™ Pierce DSS, also called disuccinimidyl suberate, is noncleavable and membrane permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of an 8-carbon spacer arm.


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces