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Thermo Scientific™ Pierce™ DSP Crosslinker

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Manufacturer: thermo scientific™  22586

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Catalog No. PI22586


Description & Specifications


Chemical Reactivity Amine-to-Amine
Cleavable Yes
Description Pierce DSP (Lomant's Reagent)
Formulation Dithiobis(succinimidylpropionate); powder solid
Membrane Permeable Yes
Molecular Weight 404.42
PEGylated No
Quantity 50mg
Sufficient For 124mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Spacer Arm Length 12Å
Water Soluble No

Thermo Scientific™ Pierce DSP Crosslinker (Lomant's Reagent) is an amine-reactive crosslinker with NHS-ester reactive ends and a cleavable disulfide bond in its spacer arm.


  • Cleavable by reducing agents
  • Membrane-permeable
  • Acylate in aqueous or organic media within two minutes at room temperature
  • Four- to five-hour half-life of ester at pH 7.0
  • Reactive groups: NHS ester (homobifunctional)
  • Reactive toward: amino groups