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Thermo Scientific™ Pierce™ DSP Crosslinker


Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Manufacturer: thermo scientific™  22586

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Catalog No. PI22586

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Description & Specifications

Specifications

Spacer Arm Length 12Å
Chemical Reactivity Amine-to-Amine
Water Soluble No
Description Pierce DSP (Lomant's Reagent)
Membrane Permeable Yes
Molecular Weight 404.42
PEGylated No
Quantity 50mg
Sufficient For 124mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Cleavable Yes
Formulation Dithiobis(succinimidylpropionate); powder solid

Thermo Scientific™ Pierce DSP Crosslinker (Lomant's Reagent) is an amine-reactive crosslinker with NHS-ester reactive ends and a cleavable disulfide bond in its spacer arm.

Highlights:

  • Cleavable by reducing agents
  • Membrane-permeable
  • Acylate in aqueous or organic media within two minutes at room temperature
  • Four- to five-hour half-life of ester at pH 7.0
  • Reactive groups: NHS ester (homobifunctional)
  • Reactive toward: amino groups