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Thermo Scientific™ Pierce™ DSP Crosslinker

Crosslink amines to amines with dithiobis succinimidyl propionate, composed of NHS-ester groups and disulfide-containing, 12.0A spacer arm and cleavable with reducing agents.

Manufacturer: thermo scientific™  PI22585

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Catalog No. PI22585

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Description & Specifications


Spacer Arm Length 12Å
Description Pierce DSP (Lomant's Reagent)
Chemical Reactivity Amine-to-Amine
PEGylated No
Water Soluble No
Formulation Dithiobis(succinimidylpropionate); powder solid
Membrane Permeable Yes
Quantity 1g
Cleavable Yes
Sufficient For 2473mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Molecular Weight 404.42

Thermo Scientific™ Pierce DSP Crosslinker (Lomant's Reagent) is an amine-reactive crosslinker with NHS-ester reactive ends and a cleavable disulfide bond in its spacer arm.


  • Cleavable by reducing agents
  • Membrane-permeable
  • Acylate in aqueous or organic media within two minutes at room temperature
  • Four- to five-hour half-life of ester at pH 7.0
  • Reactive groups: NHS ester (homobifunctional)
  • Reactive toward: amino groups