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Thermo Scientific™ Pierce™ DMP Crosslinker

Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Manufacturer: thermo scientific™  21666

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Catalog No. PI21666


Description & Specifications


Chemical Reactivity Amine-to-Amine
Cleavable No
Description Pierce DMP
Formulation Dimethyl pimelimidate-2HCl; powder solid
Membrane Permeable Yes
Molecular Weight 259.17
PEGylated No
Quantity 50mg
Sufficient For 193mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Spacer Arm Length 9.2Å
Water Soluble Yes

Thermo Scientific™ Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 7-atom spacer arm.


  • Water-soluble
  • Rapid reaction with amines at alkaline pH values (pH 8-10)
  • Amidine bond retains net charge character of protein
  • Reversible at high pH values
  • Reactive groups: imidoester (homobifunctional)
  • Reactive toward: amino groups