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Thermo Scientific™ Pierce™ DMP Crosslinker

Crosslink amines to amines with dimethyl pimelimidate (CAS 58537-94-3); composed of imidoester groups and a membrane-permeable, 7-atom spacer arm.

Manufacturer: thermo scientific™  PI21666

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Catalog No. PI21666

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Description & Specifications


Spacer Arm Length 9.2Å
PEGylated No
Molecular Weight 259.17
Cleavable No
Description Pierce DMP
Quantity 50mg
Formulation Dimethyl pimelimidate-2HCl; powder solid
Sufficient For 193mL of typical 1X (1mM) reaction solution, or approx. 25 uses at 2mg reagent per use
Membrane Permeable Yes
Water Soluble Yes
Chemical Reactivity Amine-to-Amine

Thermo Scientific™ Pierce DMP is dimethyl pimelimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of a 7-atom spacer arm.


  • Water-soluble
  • Rapid reaction with amines at alkaline pH values (pH 8-10)
  • Amidine bond retains net charge character of protein
  • Reversible at high pH values
  • Reactive groups: imidoester (homobifunctional)
  • Reactive toward: amino groups