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Thermo Scientific™ Pierce™ Carboxy-PEG-Amine Compounds


CA(PEG)n: pegylated amino acids of the form carboxy-PEG-amine; with 4 to 24 polyethylene glycol units; for surface- and molecule-pegylation applications.

Manufacturer: thermo scientific™  26122

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Catalog No. PI26122

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Description & Specifications

Specifications

Capping Group Carboxyl
Chemical Reactivity NHS esters of EDC-activated carboxylates
Cleavable No
Description Pierce CA(PEG)8
Formulation 8-unit ethyleneglycol functionalized with carboxyl and amine ends; solid
Molecular Weight 441.51
PEGylated Yes
Quantity 100mg
Sufficient For 9mL of typical 1X (25mM) reaction solution
Spacer Arm Length 33.6Å

Thermo Scientific™ Pierce CA(PEG)n Compounds are pegylated amino acids of the form carboxy-PEG-amine, where n equals 4 to 24 polyethylene glycol units, and are useful for a variety of surface- and molecule-pegylation applications.

CA(PEG)n is the abbreviation for a set of compounds having polyethylene glycol (PEG) spacers with carboxy (-COOH) and amino (-NH2) termini. The unbranched, hydrophilic, discrete-length molecules have the form Carboxy-PEGn-Amine, where the subscript “n” denotes 4, 8, 12, or 24 ethylene glycol units. The carboxyl and primary amine of each compound provide specific targets for crosslinking and other conjugation methods, making these compounds useful as PEGylation reagents.

Highlights:

  • Fully characterized PEGylation reagents with defined PEG chain lengths; molecules of discrete molecular weight for consistency of performance in protein-modification applications
  • Provided as a series of 4, 8, 12 and 24 ethylene glycol units, enabling modification procedures to be optimized for a specific application while retaining all the benefits associated with protein PEGylation
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Allows site-specific labeling or crosslinking involving primary amines or carboxyl groups on proteins or surfaces
  • Easy-to-follow instructions increase the likelihood of a successful outcome

Ordering Information:

Alternative names: Amino-dPEG-acid; Amino-PEG-carboxylic acid; Carboxy-PEO-amine

Compatible with:

Methyl-PEG-Amine Compounds, MA(PEG)n; Other Kinds of PEGylation Reagents