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Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Manufacturer: thermo scientific™  21586

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Catalog No. PI21586

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Description & Specifications


Membrane Permeable No
Cleavable No
Sufficient For 1747mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Formulation Bis(sulfosuccinimidyl) suberate; powder solid
Molecular Weight 572.43
Water Soluble Yes
Spacer Arm Length 11.4Å
PEGylated No
Chemical Reactivity Amine-to-Amine
Description Pierce BS3
Quantity 1g

Thermo Scientific™ Pierce BS3 (Sulfo-DSS) is bis(sulfosuccinimidyl)suberate, an amine-to-amine crosslinker that is homobifunctional, water-soluble, non-cleavable and membrane impermeable.


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces