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Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Manufacturer: thermo scientific™  21586

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Catalog No. PI21586

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Description & Specifications


Membrane Permeable No
Molecular Weight 572.43
PEGylated No
Quantity 1g
Sufficient For 1747mL of typical 1X (1mM) reaction solution, or approx. 500 uses at 2mg reagent per use
Chemical Reactivity Amine-to-Amine
Spacer Arm Length 11.4Å
Water Soluble Yes
Cleavable No
Description Pierce BS3
Formulation Bis(sulfosuccinimidyl) suberate; powder solid

Thermo Scientific™ Pierce BS3 (Sulfo-DSS) is bis(sulfosuccinimidyl)suberate, an amine-to-amine crosslinker that is homobifunctional, water-soluble, non-cleavable and membrane impermeable.


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces