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Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Manufacturer: thermo scientific™  21585

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Catalog No. PI21585


Description & Specifications


Chemical Reactivity Amine-to-Amine
Cleavable No
Description Pierce BS3 (Sulfo-DSS), No-Weigh Format
Formulation Bis(sulfosuccinimidyl) suberate; solid
Membrane Permeable No
Molecular Weight 572.43
PEGylated No
Quantity 8 x 2mg
Sufficient For 28mL of typical 1X (1mM) reaction solution (total), or 8 separate uses
Spacer Arm Length 11.4Å
Water Soluble Yes

Thermo Scientific™ Pierce BS3 (Sulfo-DSS) is bis(sulfosuccinimidyl)suberate, an amine-to-amine crosslinker that is homobifunctional, water-soluble, non-cleavable and membrane impermeable.


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces