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Thermo Scientific™ Pierce™ BS(PEG)n Crosslinkers

Crosslink amines to amines with these long (21.7A and 35.8A) crosslinkers composed of NHS-ester groups and 5-unit or 9-unit PEG spacer arms that enhance protein solubility.

Manufacturer: thermo scientific™  21581

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Catalog No. PI21581

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Description & Specifications


Membrane Permeable No
Molecular Weight x
PEGylated Yes
Quantity 100mg
Sufficient For 188mL of typical 1X (1mM) reaction solution, or approx. 50 uses at 2mg reagent per use
Chemical Reactivity Amine-to-Amine
Spacer Arm Length 21.7
Storage Requirements Store desiccated at -20°C, equilibrate the vial to room temperature before opening.
Water Soluble Yes
Cleavable No
Description Pierce BS(PEG)5
Formulation Bis(succinimidyl) penta(ethylene glycol); amber oil liquid

Thermo Scientific™ Pierce BS(PEG)n Crosslinkers include BS(PEG)5 and BS(PEG)9, which are bis-succinimide ester-activated PEG compounds for crosslinking between primary amines in proteins and other molecules.


  • Water-soluble polyethylene glycol (PEG) spacer arm increases solubility of crosslinked proteins
  • Excellent choice for crosslinking cell surface proteins to stabilize protein interactions
  • Reactive groups: NHS ester (homobifunctional)
  • Reactive toward: amino groups