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Specificity of this moch1ct clone was confirmed by ELISA, flow cytometry, and western blotting.Description & Specifications
DescriptionThis moch1ct monoclonal antibody recognizes human and mouse spleen tyrosine kinase (also known as SYK) when phosphorylated on tyrosine 348 (Y348). SYK is the founding member of the SYK family of kinases that also includes ZAP-70 (zeta-associated protein of 70 kD) and is expressed in hematopoietic cells, including B lymphocytes, immature (CD4, CD8 double-negative and double-positive) thymocytes, and myeloid cells, epithelial cell lines, and normal breast tissue. SYK is critical for B cell receptor (BCR) signaling and B cell development. Autophosphorylation of at Y348 is necessary for SYK to become fully catalytically active and creates a docking site for the SH2 domains of Vav, Grb2, p85 subunit of PI3 kinase, and PLC gamma.
Specificity of this moch1ct clone was confirmed by ELISA, flow cytometry, and western blotting.
|Flow Cytometry (Intracellular Staining)|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|Spleen tyrosine kinase, p72-Syk|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|