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Specificity of this CHI2S4N clone was determined by ELISA and flow cytometry.Description & Specifications
DescriptionThis CHI2S4N monoclonal antibody recognizes human and mouse signal transducer and activator of transcription 6 (STAT6) when phosphorylated on tyrosine 641. Following their phosphorylation by JAKs, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. In response to IL-4, STAT6 is phosphorylated on tyrosine 641 by JAK1 and JAK3. STAT6 signaling downstream of the IL-4 receptor promotes T cell growth and B cell production of IgE.
Specificity of this CHI2S4N clone was determined by ELISA and flow cytometry.
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|signal transducer and activator of transcription 6, pSTAT6|
|Flow Cytometry (Intracellular Staining)|
|Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage|