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Phospho-STAT4 (Y693) Mouse anti-Human, Mouse, PE, Clone: 4LURPIE, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $448.05

Specifications

Antigen Phospho-STAT4 (Y693)
Clone 4LURPIE
Host Species Mouse
Gene Alias Signal transducer and activator of transcription 4
Species Reactivity Human, Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122417

 
affymetrix
12904441
25 tests Each for $187.05

501129226

 
affymetrix
12-9044-42
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen Phospho-STAT4 (Y693)
Clone 4LURPIE
Host Species Mouse
Gene Alias Signal transducer and activator of transcription 4
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

This 4LURPIE monoclonal antibody recognizes human and mouse signal transducer and activator of transcription 4 (STAT4) when phosphorylated on tyrosine 693 (Y693). STAT proteins are activated by ligand binding to cytokine receptors that associate with Janus kinase (JAK) family members. Following their phosphorylation by JAK proteins, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. STAT4 is activated by IL-12 or type 1 IFN (IFN alpha, IFN beta). STAT4 is required for optimal Th1 differentiation in vivo. Interestingly, although IFN alpha can lead to phosphorylation of STAT4 in mouse T cells, the phosphorylation is much weaker than that induced by IL-12 and is transient. Thus, IFN alpha phosphorylation of STAT4 does not contribute to STAT4-mediated Th1 development or IFN gamma production by Th1 cells in mice. In contrast, IFN alpha does promote Th1 development and function of human CD4+ T cells.

Specificity of this 4LURPIE clone was determined by ELISA and flow cytometry.