missing translation for 'onlineSavingsMsg'
Learn More
Please login to your online account to display your discounted pricing

Phospho-STAT4 (Y693) Mouse anti-Human, Mouse, PE, Clone: 4LURPIE, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $448.05

Specifications

Antigen Phospho-STAT4 (Y693)
Clone 4LURPIE
Host Species Murine
Gene Alias Signal transducer and activator of transcription 4
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122417 Life Technologies
LS12904441
25 Tests Each for $187.05
501129226 Life Technologies
LS12904442
100 Tests Each for $448.05
Specifications

Description

This 4LURPIE monoclonal antibody recognizes human and mouse signal transducer and activator of transcription 4 (STAT4) when phosphorylated on tyrosine 693 (Y693). STAT proteins are activated by ligand binding to cytokine receptors that associate with Janus kinase (JAK) family members. Following their phosphorylation by JAK proteins, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. STAT4 is activated by IL-12 or type 1 IFN (IFN alpha, IFN beta). STAT4 is required for optimal Th1 differentiation in vivo. Interestingly, although IFN alpha can lead to phosphorylation of STAT4 in mouse T cells, the phosphorylation is much weaker than that induced by IL-12 and is transient. Thus, IFN alpha phosphorylation of STAT4 does not contribute to STAT4-mediated Th1 development or IFN gamma production by Th1 cells in mice. In contrast, IFN alpha does promote Th1 development and function of human CD4+ T cells.

Specificity of this 4LURPIE clone was determined by ELISA and flow cytometry.
Description & Specifications

Specifications

Phospho-STAT4 (Y693)
Murine
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
4LURPIE
Signal transducer and activator of transcription 4
Flow Cytometry (Intracellular Staining)
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.25μg)/test