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Phospho-STAT3 (Y705) Mouse anti-Human, Mouse, PE, Clone: LUVNKLA, eBioscience™

Mouse Monoclonal Antibody

$191.40 - $456.75

Specifications

Antigen Phospho-STAT3 (Y705)
Clone LUVNKLA
Host Species Murine
Gene Alias Signal transducer and activator of transcription 3
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122407 Life Technologies
LS12903341
25 Tests Each for $191.40
501122408 Life Technologies
LS12903342
100 Tests Each for $456.75
Specifications

Description

This LUVNKLA monoclonal antibody recognizes human and mouse signal transducer and activator of transcription 3 (STAT3) when phosphorylated on tyrosine 705 (Y705). The STAT family represents seven transcription factors (STATs 1, 2, 3, 4, 5A, 5B, and 6) that are involved in many cellular processes including apoptosis, cell differentiation, and proliferation in a cell type- and cytokine-specific manner. STAT proteins are activated by ligand binding to cytokine receptors that associate with Janus kinase (JAK) family members.

Following their phosphorylation by JAKs, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. STAT3 is activated downstream of numerous cytokines including interferons, IL-5, IL-6, IL-10, and LIF. STAT3 is important for the differentiation of Th17 cells and mediates a variety of cellular processes including cell growth and survival. The importance of STAT3 is highlighted by both loss-of-function and gain-of-function mutations. Deletion of STAT3 in T cells results in decreased IL-6- and IL-2-mediated proliferation, while deletion of STAT3 in neutrophils and macrophages results in increased susceptibility to LPS-induced endotoxic shock and increased production of the pro-inflammatory cytokines IL-6 and TNF alpha. Hyper STAT3 activity is associated with poor prognosis of many different cancers.
Description & Specifications

Specifications

Phospho-STAT3 (Y705)
Murine
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
LUVNKLA
Signal transducer and activator of transcription 3
Flow Cytometry (Intracellular Staining)
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.06μg)/test