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This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.Description & Specifications
DescriptionThis HNDZ55 monoclonal antibody recognizes human SH2 domain-containing leukocyte protein of 76 kD (SLP-76) when phosphorylated on tyrosine 128 (Y128). SLP-76 is phosphorylated by ZAP-70 downstream of the T cell receptor (TCR). SLP-76 contains an acidic region that includes a PEST domain, several tyrosine residues that are phosphorylated following TCR ligation, a proline-rich domain, and an SH2 domain. Numerous proteins associate with SLP-76 including Vav1, GADS, and PLC gamma 1, supporting the notion that SLP-76 functions as a critical adaptor protein downstream of the TCR. SLP-76-deficient T cell lines or mice deficient in SLP-76 have shown that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.
|Flow Cytometry (Intracellular Staining)|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|Lymphocyte cytosolic protein 2, LCP2|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|