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Phospho-mTOR (S2448) Mouse anti-Human, Mouse, eFluor 660, Clone: MRRBY, eBioscience™

Mouse Monoclonal Antibody

$174.24 - $447.48

Specifications

Antigen Phospho-mTOR (S2448)
Clone MRRBY
Host Species Murine
Gene Alias mammalian target of rapamycin, FRAP, RAFT
Applications Flow Cytometry (Intracellular Staining)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124519 Life Technologies
LS50971841
25 Tests Each for $174.24
501124520 Life Technologies
LS50971842
100 Tests Each for $447.48
Specifications

Description

This MRRBY monoclonal antibody recognizes human and mouse mammalian target of rapamycin (also known as mTOR, FRAP, RAFT) when phosphorylated on S2448. mTOR is a serine/threonine protein kinase that functions as an ATP and amino acid sensor as well as to balance nutrient availability with cell growth, proliferation, motility, survival, protein synthesis, and transcription. Activated mTOR increases production of enzymes necessary for glycolysis and controls the uptake of glucose and other nutrients. Increased glucose uptake and metabolism helps fulfill the energy needs for mTOR-driven cell growth and proliferation. When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of the eIF4E inhibitor, 4E-BP1. mTOR is phosphorylated at S2448 via the PI3 kinase/Akt signaling pathway and is autophosphorylated at Ser2481. Due to its critical role in regulation of cell growth, survival, and metabolism, and because it is often abnormally regulated in tumors, mTOR is under investigation as a potential target for anti-cancer therapy.
Description & Specifications

Specifications

Phospho-mTOR (S2448)
Murine
Flow Cytometry (Intracellular Staining)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.5μg)/test
MRRBY
mammalian target of rapamycin, FRAP, RAFT
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer