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Phospho-Mcl-1 (S159) Mouse anti-Human, Mouse, PE, Clone: RBCERNR, eBioscience™

Mouse Monoclonal Antibody

$183.48 - $447.48

Specifications

Antigen Phospho-Mcl-1 (S159)
Clone RBCERNR
Host Species Murine
Gene Alias BCL2L3, EAT
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122413 Life Technologies
LS12903841
25 Tests Each for $183.48
501122414 Life Technologies
LS12903842
100 Tests Each for $447.48
Specifications

Description

This RBCERNR monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1) when phosphorylated on serine 159 (S159). Mcl-1 is an anti-apoptotic protein that is a member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. PI3K activation of AKT results in the phosphorylation of GSK3 beta at serine 9 (S9) resulting in destabilization and degradation of GSK3 beta. Loss of GSK3 beta prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.
Description & Specifications

Specifications

Phospho-Mcl-1 (S159)
Murine
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
RBCERNR
BCL2L3, EAT
Flow Cytometry (Intracellular Staining)
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test