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Phospho-Mcl-1 (S159) Mouse anti-Human, Mouse, APC, Clone: RBCERNR, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $491.55

Specifications

Antigen Phospho-Mcl-1 (S159)
Clone RBCERNR
Host Species Mouse
Gene Alias BCL2L3, EAT
Species Reactivity Human, Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123208

 
affymetrix
17903841
25 tests Each for $201.55

501123209

 
affymetrix
17903842
100 tests Each for $491.55
Description & Specifications

Specifications

Antigen Phospho-Mcl-1 (S159)
Clone RBCERNR
Host Species Mouse
Gene Alias BCL2L3, EAT
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

This RBCERNR monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1) when phosphorylated on serine 159 (S159). Mcl-1 is an anti-apoptotic protein that is a member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. PI3K activation of AKT results in the phosphorylation of GSK3 beta at serine 9 (S9) resulting in destabilization and degradation of GSK3 beta. Loss of GSK3 beta prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.