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Phospho-I kappa B alpha (IKB-a) (S32/S36) Mouse anti-Human, Mouse, eFluor 660, Clone: RILYB3R, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $477.05

Specifications

Antigen Phospho-I kappa B alpha (IKB-a) (S32/S36)
Clone RILYB3R
Host Species Murine
Gene Alias Inhibitor of kappa B alpha
Species Reactivity Human, Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124486 Life Technologies
LS50903541
25 Tests Each for $187.05
501124487 Life Technologies
LS50903542
100 Tests Each for $477.05
Specifications

Description

This RILYB3R monoclonal antibody recognizes human and mouse nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (I kappa B alpha) when phosphorylated on serines 32 and 36 (S32/S36). I kappa B alpha is one member of a family of cellular proteins that functions to inhibit classical/canonical NF-kappa B signaling by masking the nuclear localization signals (NLS) of NF-kappa B proteins and keeping them sequestered in an inactive state in the cytoplasm. Classical/canonical NF-kappa B signaling is initiated in response to myriad stimuli including engagement of T cell and B cell receptors, growth factors, and inflammatory stimuli (reactive oxygen species, TNF alpha, IL-1) and results in the activation of the I kappa B kinase (IKK) complex that includes IKK alpha, IKK beta, and NEMO. IKK phosphorylates I kappa B alpha resulting in its ubiquitination, degradation, and subsequent translocation of NF-kappa B transcription factor proteins into the nucleus.
Description & Specifications

Specifications

Phospho-I kappa B alpha (IKB-a) (S32/S36)
Murine
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
RILYB3R
Inhibitor of kappa B alpha
Flow Cytometry (Intracellular Staining)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test