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Phospho-I kappa B alpha (IKB-a) (S32/S36) Mouse anti-Human, Mouse, eFluor 660, Clone: RILYB3R, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $448.05

Specifications

Antigen Phospho-I kappa B alpha (IKB-a) (S32/S36)
Clone RILYB3R
Host Species Mouse
Gene Alias Inhibitor of kappa B alpha
Species Reactivity Human, Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124486

 
affymetrix
50903541
25 tests Each for $187.05

501124487

 
affymetrix
50903542
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen Phospho-I kappa B alpha (IKB-a) (S32/S36)
Clone RILYB3R
Host Species Mouse
Gene Alias Inhibitor of kappa B alpha
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This RILYB3R monoclonal antibody recognizes human and mouse nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (I kappa B alpha) when phosphorylated on serines 32 and 36 (S32/S36). I kappa B alpha is one member of a family of cellular proteins that functions to inhibit classical/canonical NF-kappa B signaling by masking the nuclear localization signals (NLS) of NF-kappa B proteins and keeping them sequestered in an inactive state in the cytoplasm. Classical/canonical NF-kappa B signaling is initiated in response to myriad stimuli including engagement of T cell and B cell receptors, growth factors, and inflammatory stimuli (reactive oxygen species, TNF alpha, IL-1) and results in the activation of the I kappa B kinase (IKK) complex that includes IKK alpha, IKK beta, and NEMO. IKK phosphorylates I kappa B alpha resulting in its ubiquitination, degradation, and subsequent translocation of NF-kappa B transcription factor proteins into the nucleus.