Please login to your online account to display your discounted pricing

phospho Chk2 Mouse anti-Human, Mouse, PE, Clone: ebchk2, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $477.05

Specifications

Antigen phospho Chk2
Clone ebchk2
Host Species Mouse
Gene Alias Checkpoint kinase 2
Species Reactivity Human, Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122443

 
affymetrix
12950841
25 tests Each for $201.55

501122444

 
affymetrix
12950842
100 tests Each for $477.05
Description & Specifications

Specifications

Antigen phospho Chk2
Clone ebchk2
Host Species Mouse
Gene Alias Checkpoint kinase 2
Species Reactivity Human, Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This ebchk2 monoclonal antibody recognizes human and mouse Checkpoint Kinase 2 (Chk2) when phosphorylated on threonine 68 (T68). Chk2 is a cell cycle checkpoint regulator and tumor suppressor. Along with Chk1, it plays a critical role in the cellular response to DNA damage, and is particularly important during G2/M transition. Chk2 is activated via phosphorylation on T68 by the kinase ATM, which responds primarily to double-stranded DNA breaks. Upon activation, Chk2 functions include inhibition of Cdc25 family phosphatases and activation of p53, both of which prevent progression of the cell cycle. Abnormal regulation of the ATM-Chk2 pathway is often observed in cancer.