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Phospho-BTK/ITK (Y551/Y511) Mouse anti-Human, Mouse, eFluor 660, Clone: M4G3LN, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $506.05

Specifications

Antigen Phospho-BTK/ITK (Y551/Y511)
Clone M4G3LN
Host Species Mouse
Species Reactivity Human, Mouse
Applications Immunohistochemistry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124481

 
affymetrix
50901580
25μg Each for $201.55

501124482

 
affymetrix
50901582
100μg Each for $506.05
Description & Specifications

Specifications

Antigen Phospho-BTK/ITK (Y551/Y511)
Clone M4G3LN
Host Species Mouse
Species Reactivity Human, Mouse
Applications Immunohistochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Regulatory Status RUO
Conjugate eFluor 660
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This M4G3LN monoclonal antibody recognizes human and mouse Bruton’s tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively.

In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.

Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting.