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Phospho-BTK/ITK (Y551/Y511) Mouse anti-Human, Mouse, eFluor 660, Clone: M4G3LN, eBioscience™

Mouse Monoclonal Antibody

$205.90 - $506.05

Specifications

Antigen Phospho-BTK/ITK (Y551/Y511)
Clone M4G3LN
Host Species Murine
Species Reactivity Human, Mouse
Applications Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin)
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124481 Life Technologies
LS50901580
25μg Each for $205.90
501124482 Life Technologies
LS50901582
100μg Each for $506.05
Specifications

Description

This M4G3LN monoclonal antibody recognizes human and mouse Bruton’s tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively.

In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.

Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting.
Description & Specifications

Specifications

Phospho-BTK/ITK (Y551/Y511)
Murine
Immunohistochemistry,Immunohistochemistry (Formalin/Paraffin)
eFluor 660
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
M4G3LN
Human, Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer